Nanomedicine in the diagnosis and therapy of neurodegenerative disorders.
作者： A.V. Kabanov , H.E. Gendelman
DOI: 10.1016/J.PROGPOLYMSCI.2007.05.014
关键词: Disease 、 Disease outcome 、 Stroke 、 Population 、 Nanostructured materials 、 Nanomedicine 、 Degenerative disease 、 Intensive care medicine 、 Medicine 、 Amyotrophic lateral sclerosis
摘要: Neurodegenerative and infectious disorders including Alzheimer's Parkinson's diseases, amyotrophic lateral sclerosis, stroke are rapidly increasing as population's age. disease alone currently affects 4.5 million Americans, more than $100 billion is spent per year on medical institutional care for affected people. Such numbers will double in the ensuing decades. Currently diagnosis all made, large measure, clinical grounds laboratory neuroimaging tests confirm what seen by routine examination. Achieving early would enable improved outcomes. Drugs, vaccines or regenerative proteins present "real" possibilities positively affecting outcomes, but limited that their entry into brain commonly restricted across blood-brain barrier. This review highlights how these obstacles can be overcome polymer science nanotechnology. approaches may improve diagnostic therapeutic New developments coupled with cell-based delivery strategies support notion diseases now have options show outcomes advances nanomedicine.
elsevier.com
sci-hub.se 参考文章(362)
Donald W. Miller, Elena V. Batrakova, Timothy O. Waltner, Valery Yu. Alakhov, Alexander V. Kabanov, Interactions of pluronic block copolymers with brain microvessel endothelial cells: evidence of two potential pathways for drug absorption. Bioconjugate Chemistry. ,vol. 8, pp. 649- 657 ,(1997) , 10.1021/BC970118D
William A. Banks, Sandra M. Robinson, Avindra Nath, Permeability of the blood-brain barrier to HIV-1 Tat. Experimental Neurology. ,vol. 193, pp. 218- 227 ,(2005) , 10.1016/J.EXPNEUROL.2004.11.019
Mustafa O. Guler, Jonathan K. Pokorski, Daniel H. Appella, Samuel I. Stupp, Enhanced oligonucleotide binding to self-assembled nanofibers Bioconjugate Chemistry. ,vol. 16, pp. 501- 503 ,(2005) , 10.1021/BC050053B
Elena V. Batrakova, Shu Li, Yili Li, Valery Yu. Alakhov, Alexander V. Kabanov, Effect of pluronic P85 on ATPase activity of drug efflux transporters Pharmaceutical Research. ,vol. 21, pp. 2226- 2233 ,(2004) , 10.1007/S11095-004-7675-5
J. Folkman, D. M. Long, R. Rosenbaum, Silicone Rubber: A New Diffusion Property Useful for General Anesthesia Science. ,vol. 154, pp. 148- 149 ,(1966) , 10.1126/SCIENCE.154.3745.148
Lei Ping Yu, Pei Yuan Jia, Qian Li, Guo Zhang Jin, Man Ji Sun, Shao Ping Wu, Ai Ling Fu, Yu Xia Wang, A novel therapeutic approach to 6-OHDA-induced Parkinson's disease in rats via supplementation of PTD-conjugated tyrosine hydroxylase. Biochemical and Biophysical Research Communications. ,vol. 346, pp. 1- 6 ,(2006) , 10.1016/J.BBRC.2006.03.247
Peter Flachenecker, Epidemiology of neuroimmunological diseases Journal of Neurology. ,vol. 253, pp. v2- v8 ,(2006) , 10.1007/S00415-006-5001-3
Justin C. McArthur, HIV dementia: an evolving disease. Journal of Neuroimmunology. ,vol. 157, pp. 3- 10 ,(2004) , 10.1016/J.JNEUROIM.2004.08.042
Kopparam Manjunath, Vobalaboina Venkateswarlu, Pharmacokinetics, tissue distribution and bioavailability of nitrendipine solid lipid nanoparticles after intravenous and intraduodenal administration Journal of Drug Targeting. ,vol. 14, pp. 632- 645 ,(2006) , 10.1080/10611860600888850
Atsushi Harada, Kazunori Kataoka, Novel Polyion Complex Micelles Entrapping Enzyme Molecules in the Core. 2. Characterization of the Micelles Prepared at Nonstoichiometric Mixing Ratios Langmuir. ,vol. 15, pp. 4208- 4212 ,(1999) , 10.1021/LA981087T