Nanoparticles for sensing and potential gene therapy in neuroscience

作者: Yupu Diao , Qingpeng Yu , Lu Fan , Jiayi Zhang , Nan Qin

DOI: 10.1234/NANO120103

关键词:

摘要: Nanotechnology has been actively employed for applications in neuroscience, particularly passive drug delivery through brain-blood barrier treatment of neurological disorders. Recent progresses have made using nanoparticles to sense neural activities, including electrical spikes and nano-scale synaptic events. Nanoparticle-mediated gene transfer also shown successfully transfect neuronal cells non-viral plamid DNAs. This review summarizes some these recent progresses, which will hopefully open windows novel the rapidly developing neuroscience field. © Global Scientific Publishers 2012

参考文章(69)
Hu Peng, Jason Myers, Xiaohong Fang, Ewa K Stachowiak, *, 1, Pamela A Maher, Gabriel G Martins, Gabriela Popescu, Ronald Berezney, Michal K Stachowiak, Integrative nuclear FGFR1 signaling (INFS) pathway mediates activation of the tyrosine hydroxylase gene by angiotensin II, depolarization and protein kinase C Journal of Neurochemistry. ,vol. 81, pp. 506- 524 ,(2002) , 10.1046/J.1471-4159.2002.00833.X
Josep M. Canals, Núria Checa, Sònia Marco, Peter Åkerud, Alice Michels, Esther Pérez-Navarro, Eduard Tolosa, Ernest Arenas, Jordi Alberch, Expression of brain-derived neurotrophic factor in cortical neurons is regulated by striatal target area. The Journal of Neuroscience. ,vol. 21, pp. 117- 124 ,(2001) , 10.1523/JNEUROSCI.21-01-00117.2001
Michael A. Paradiso, Mark F. Bear, Barry W. Connors, Neuroscience: Exploring the Brain ,(1996)
Yukiko Goda, Bernardo L. Sabatini, Synaptic function and regulation. Current Opinion in Neurobiology. ,vol. 21, pp. 205- 207 ,(2011) , 10.1016/J.CONB.2011.03.004
Q. Zhang, Y.-Q. Cao, R. W. Tsien, Quantum dots provide an optical signal specific to full collapse fusion of synaptic vesicles Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 17843- 17848 ,(2007) , 10.1073/PNAS.0706906104
A.V. Kabanov, H.E. Gendelman, Nanomedicine in the diagnosis and therapy of neurodegenerative disorders. Progress in Polymer Science. ,vol. 32, pp. 1054- 1082 ,(2007) , 10.1016/J.PROGPOLYMSCI.2007.05.014
ERWIN NEHER, BERT SAKMANN, Single-channel currents recorded from membrane of denervated frog muscle fibres Nature. ,vol. 260, pp. 799- 802 ,(1976) , 10.1038/260799A0
I. Klejbor, E.K. Stachowiak, D.J. Bharali, I. Roy, I. Spodnik, J. Morys, E.J. Bergey, P.N. Prasad, M.K. Stachowiak, ORMOSIL nanoparticles as a non-viral gene delivery vector for modeling polyglutamine induced brain pathology. Journal of Neuroscience Methods. ,vol. 165, pp. 230- 243 ,(2007) , 10.1016/J.JNEUMETH.2007.06.011