Calponin and h-caldesmon in soft tissue tumors: consistent h-caldesmon immunoreactivity in gastrointestinal stromal tumors indicates traits of smooth muscle differentiation.

摘要: Currently, the immunohistochemical evaluation of smooth muscle differentiation is usually based on desmin, which also reacts with skeletal and not present in all tumors, alpha-smooth actin, myoepithelial cells. Neither marker typically gastrointestinal stromal tumors (GISTs), previously classified as or presently often muscle/stromal tumors. Two cytoskeleton-associated actin-binding proteins, calponin (CALP) h-caldesmon (HCD), are putative markers that react myoepithelia. These particular interest analysis tumors; neither them has been extensively documented soft tissue In this study, we evaluated selected normal reactive tissues more than 250 mesenchymal for CALP HCD. Both were expressed parenchymal vascular cells various organs reacted myofibroblasts desmoplastic stroma. All our 25 benign from locations positive HCD, most retroperitoneal uterine leiomyosarcomas. HCD was specific, because myofibroblastic lesions. The common reactivity malignant fibrous histiocytomas suggests a combination these GISTs (c-kit positive, actin negative) showed nearly consistent reactivity, suggesting traits differentiation. negative expression pattern similar to actin. Although nonmuscle, nonmyofibroblastic synovial sarcomas streaks CALP-positive unknown significance. should be explored identify cell