Iridium-192 Afterloading for Boosting the Tumor Bed

摘要: Interstitial radiotherapy for breast cancer as an alternative to radical mastectomy was first recommended by Janeway in 1917; 1939 Keynes (Robinson 1986), who also using radium needles, stated that interstitial good with less mutilation and edema of the arm 1986). With introduction cobalt machines linear accelerators, therapy confined delivery boost doses, especially France, where a new dosimetry system developed Pierquin Dutreix (1967) iridium wires after-loading technique (Paris system). Many thousands patients have had conservation (BCT) since then, results prospectively randomized trials (Fisher et al. 1985; Veronesi 1983; Sarrazin van Dongen 1987) well data from retrospective studies (Amalric Calle Bartelink 1988; Loper 1987; Limbergen Clark clearly confirm conclusions pioneers field: For early up 5 cm diameter BCT gives equal respect survival local control. Local control rates Ti T2 cancers treated vary 91% 98% at years’, 87% 92% 10 years’ Amalric 1987), 80% 85% 15 20 follow-up (Harris 1984; Kurtz 1987).