Swelling of and Drug Release from Monoglyceride-Based Drug Delivery Systems

摘要: Depending on the water content, unsaturated monoglycerides form various liquid crystalline phases, which can be used as sustained-release carriers. The aim of this study was to investigate uptake and drug release from melt-congealed monoglyceride-based monoolein monolinolein followed second-order swelling kinetics levelled off at about 50% a highly viscous cubic phase formed. rapid formation suggested that occurred mainly phase. square-root time relationship during initial Chlorpheniramine maleate, an amphiphilic not completely released because binding rate increased maximum decreased with increasing temperature. could controlled by varying surface-to-volume ratio, loading, content lipid matrix. It independent source monoolein.