Hormone Replacement Therapy and Its Effects on Human Hearing

摘要: Hormone therapies can have very dramatic effects upon hearing abilities, depending on the timing, duration, and nature of hormones. Overall, estrogen tends to be beneficial hearing, consistent with its generally neuroprotective neuromodulatory actions for neural sensory systems. Indeed, menopausal women tend benefit from hormone replacement therapy (HRT) in terms but other serious side effects, including ovarian, uterine, breast cancer risks, taken into account carefully. The most common form HRT prescribed clinically, so called “combination” HRT, consists combined progestin/progesterone. largest clinical research study date post-menopausal revealed decreases auditory sensitivity (audiogram thresholds), declines otoacoustic emission levels, worse performance hearing-in-background noise tests relative controls (women who had never HRT). Other hormones, such as aldosterone, may older individuals reduced serum levels this mineralocorticoid hormone. Thyroxine, given patients suffering hypothyroidism, also hearing. And finally, examination a series emissions evoked potential studies different gender groups suggests that pre- or post-natal exposures higher testosterone correlate processing.