Entecavir therapy for adefovir-resistant hepatitis B virus infection in kidney and liver allograft recipients.
作者： Nassim Kamar , Olivier Milioto , Laurent Alric , Labib El Kahwaji , Olivier Cointault
DOI: 10.1097/TP.0B013E3181806C8C
关键词:
摘要: The aim of our study was to assess the efficacy and safety entecavir in kidney- liver-transplant recipients with chronic hepatitis B virus (HBV) infection. Ten male transplant patients HBV infection (eight two patients), who have become adefovir (n=9) or lamivudine-resistant (n=1) were given at 0.5 1 mg/d. All HBs Ag positive: six HBe Ag(-)/HBe Ab(+), four Ag(+)/HBe Ab(-). After a median follow-up 16.5 months, therapy associated significant decrease DNA viral load, that is, 3.86 (2.71-6.46) log10 copies/mL baseline down 2.94 (2.15-4) last (P=0.004). Rate clearance 50% both HBeAg(+) HBeAg(-) patients. There no changes renal function hematological parameters. This demonstrates is safe efficient HBV(+) organ-transplant
lww.com 
sci-hub.se 参考文章(22)
F. Degos, C. Lugassy, C. Degott, A. Debure, F. Carnot, V. Thiers, P. Tiollais, H. Kreis, C. Brechot, Hepatitis B virus and hepatitis B-related viral infection in renal transplant recipients: A prospective study of 90 patients Gastroenterology. ,vol. 94, pp. 151- 156 ,(1988) , 10.1016/0016-5085(88)90623-3
Robert G. Gish, Improving outcomes for patients with chronic hepatitis B. Current Gastroenterology Reports. ,vol. 9, pp. 14- 22 ,(2007) , 10.1007/S11894-008-0016-9
Masako Fukuda, Haruhisa Nakao, Fumio Tsuda, Hiroaki Okamoto, Yuzo Miyakawa, Makoto Mayumi, Satoshi Tanaka, Makoto Yoshiba, Shiro Iino, A common-source outbreak of fulminant hepatitis B in hemodialysis patients induced by precore mutant Kidney International. ,vol. 48, pp. 1972- 1978 ,(1995) , 10.1038/KI.1995.499
Sophie Fornairon, Stanislas Pol, Christophe Legendre, Fran??oise Carnot, Marie-France Mamzer-Bruneel, Christian Brechot, Henri Kreis, The long-term virologic and pathologic impact of renal transplantation on chronic hepatitis B virus infection. Transplantation. ,vol. 62, pp. 297- 299 ,(1996) , 10.1097/00007890-199607270-00025
Robert G. Gish, Timothy McCashland, Hepatitis B in liver transplant recipients Liver Transplantation. ,vol. 12, pp. S54- S64 ,(2006) , 10.1002/LT.20950
Ahmad Obaid Shakil, Leslie Lilly, Peter Angus, Guido Gerken, Neal Thomas, Michelle Jean, Shobha Joshi, Entecavir significantly reduces viral load in liver transplant recipients failing lamivudine therapy for chronic hepatitis B infection Journal of Hepatology. ,vol. 36, pp. 122- ,(2002) , 10.1016/S0168-8278(02)80433-0
H.J. de Silva, A.S. Dassanayake, A. Manamperi, A.P. de Silva, Treatment of Lamivudine-Resistant Hepatitis B Infection in Post–Renal Transplant Patients With Adefovir Dipivoxil: Premiminary Results Transplantation Proceedings. ,vol. 38, pp. 3118- 3120 ,(2006) , 10.1016/J.TRANSPROCEED.2006.08.186
T. Walter, J. Dumortier, O. Guillaud, V. Hervieu, P. Paliard, J.-Y. Scoazec, O. Boillot, Rejection under alpha interferon therapy in liver transplant recipients. American Journal of Transplantation. ,vol. 7, pp. 177- 184 ,(2007) , 10.1111/J.1600-6143.2006.01590.X
Lionel Rostaing, Sabine Henry, Jean-Marc Cisterne, Michel Duffaut, Josette Icart, Dominique Durand, Efficacy and safety of lamivudine on replication of recurrent hepatitis B after cadaveric renal transplantation. Transplantation. ,vol. 64, pp. 1624- 1627 ,(1997) , 10.1097/00007890-199712150-00025
Marie Hélène Chabannier, Dominique Durand, Lionel Rostaing, Anne Modesto, Emmanuel Baron, JeanMarc Cisterne, Acute renal failure in kidney transplant patients treated with interferon alpha 2b for chronic hepatitis C. Nephron. ,vol. 74, pp. 512- 516 ,(1996) , 10.1159/000189444