Side effects of long-term oral antiviral therapy for hepatitis B.

摘要: The aim of this review is to summarize the safety profile five approved oral nucleoside analogs used treat chronic hepatitis B virus (HBV) infection, focusing on both class adverse effects and those that have been reported with individual agents, as well their in pregnancy. All a "Black Box" warning because potential for inhibition human DNA polymerase gamma involved mitochondrial replication. A reduction intracellular levels can lead varying clinical manifestations toxicity (i.e., neuropathy, myopathy, lactic acidosis), but these side are rarely antiviral agents active against HBV. Adefovir tenofovir associated dose-dependent usually reversible proximal renal tubular toxicity. For reasons, patients receiving should be monitored dose modified insufficiency. Prolonged use has also reduced bone mineral density immunodeficiency prospective studies HBV infection lacking. Telbivudine treatment moderate serum creatine phosphokinase elevations up 12% patients. There few during According Antiretroviral Pregnancy Registry, incidence birth defects lamivudine pregnancy not increased. Studies long-term therapy analogs, alone combination, needed further children, elderly, pregnant women,