Elevated Lifetime Lead Exposure Impedes Osteoclast Activity and Produces an Increase in Bone Mass in Adolescent Mice

摘要: The heavy metal lead (Pb) has a deleterious effect on skeletal health. Because bone mass is maintained through balance of formation and resorption, it important to understand the Pb levels osteoblastic osteoclastic activity. exposure associated with low in animal models human populations; however, correlation between dosing corresponding been poorly explored. Thus, mice were exposed increasing at higher (500 ppm), there was unexpectedly an increase femur-tibial by 3 months age. This contrary several studies alluded earlier. Increased volume (BV) accompanied significant cortical thickness femur trabecular that extended beyond epiphyseal area into marrow cavity. Subsequent evaluations revealed osteoclast numbers high exposure, but deficiency These findings substantiated observed increases resorption-altering hormones calcitonin estrogen. In addition we found pro-osteoclastic nuclear factor-kappa beta (NF-κB) pathway activity dose dependently elevated Pb, both in vivo in vitro. However, ability osteoclasts resorb depressed presence media within test wafers. indicate disrupts early life accrual may involve disruption study accentuates dependent variation consequent effects