Circuitry of nuclear factor kappaB signaling.

摘要: Over the past few years, transcription factor nuclear (NF)-kappaB and proteins that regulate it have emerged as a signaling system of pre-eminent importance in human physiology an increasing number pathologies. While NF-kappaB is present all differentiated cell types, its discovery early characterization were rooted understanding B-cell biology. Significant research efforts over two decades yielded large body literature devoted to NF-kappaB's functioning immune system. has been found play roles many different compartments during differentiation cells development lymphoid organs activation. effector pathways emanating from receptors, including those inflammatory tumor necrosis Toll-like receptor superfamilies. With this review, we hope provide historical context summarize diverse physiological functions before focusing on recent advances elucidating molecular mechanisms mediate type-specific stimulus-specific pleiotropic Understanding genetic regulatory circuitry functionalities involves system-wide measurements, biophysical studies, computational modeling.