Changes in acquired immunodeficiency syndrome-related non-Hodgkin lymphoma in the era of highly active antiretroviral therapy: incidence, presentation, treatment, and survival.

摘要: BACKGROUND The authors sought to determine whether the availability of highly active antiretroviral therapy (HAART) coincided with changes in epidemiology acquired immunodeficiency syndrome (AIDS)-related non-Hodgkin lymphoma (NHL). METHODS Cancer registry data from 1988–2000 were linked AIDS 1981 July 2003 for San Diego County identify 537 AIDS-NHL patients. By using total number patients who alive as 1 annually population denominator, average annual incidence NHL was estimated among pre-HAART period (1988–1995) and post-HAART (1996–2000). The chi-square test used compare proportions, a Cox proportional hazards model survival between periods. RESULTS The decreased 29.6 per 1000 person-years 6.5 post-HAART. proportion had central nervous system (CNS) origin 28% 17% Among systemic NHL, 54% received chemotherapy pre-HAART, 72% percentage intermediate-grade increased 33% 49% post-HAART, high-grade 38% 19%, respectively. A diagnosis human virus infection preceding Stage IV associated worse survival, whereas better survival. median 4 months 9 post-HAART. CONCLUSIONS Since introduction HAART, there has been decrease CNS AIDS. systemic, AIDS-related histology, use chemotherapy, improved Cancer 2006. © 2005 American Society.