Chemotherapy for Human Immunodeficiency Virus–Associated Non-Hodgkin’s Lymphoma in Combination With Highly Active Antiretroviral Therapy

摘要: PURPOSE: This study investigated the efficacy, toxicity, and pharmacokinetic interactions resulting from simultaneous combination chemotherapy highly active antiretroviral therapy (HAART) for patients with human immunodeficiency virus (HIV)-associated non-Hodgkin’s lymphoma (NHL). In addition, effects on viral load, CD4 counts, opportunistic infections were examined use of combined HAART. PATIENTS AND METHODS: Sixty-five previously untreated measurable disease at any stage HIV-associated NHL intermediate or high grade entered onto this 17 different centers. The first 40 received reduced doses cyclophosphamide doxorubicin, vincristine prednisone (modified CHOP [mCHOP]), whereas subsequent 25 full granulocyte colony-stimulating factor (G-CSF). All also stavudine, lamivudine,...