Genetics of chronic post-surgical pain: a crucial step toward personal pain medicine Genetique de la douleur chronique post chirurgicale: une etape cruciale vers une medecine personnalisee de la douleur

摘要: Purpose Most patients who undergo surgery or experience a traumatic injury suffer from acute pain that subsides once tissues heal. Nevertheless, the remains in 15-30% of patients, sometimes for life, and this chronic post-surgical (CPSP) can result suffering, depression, anxiety, sleep disturbance, physical incapacitation, an economic burden. The incorporation genetic knowledge is expected to lead development more effective means prevent manage CPSP using tools personalized medicine. purpose review article provide update on current state genetics its future potential. Principle findings large variability amongst undergoing similar suggests individual factors are significant contributors CPSP, raising possibility influenced by determinants. Heritability estimates suggest about half variance levels attributable variation. These identifying underpinnings may improvements treatment. Analyzing patients’ DNA sequences, blood salivary biomarkers, as well their analgesic responses medications will facilitate developing insights into pathophysiology inform predictive algorithms determine patient’s likelihood even prior surgery. could treatment regimens protect against transition chronicity traumatically injured those scheduled better therapy have already developed CPSP.