Adenylate cyclase responsiveness of human insulinomas

作者: M. Veroni , V. Michelangeli , T. Heaney , K. Ng , N. Partridge

DOI: 10.1055/S-2007-1019238

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摘要: Adenylate cyclase activity was assayed in a crude particulate fraction of one benign and malignant human insulinoma. both tumours responded to 5'-guanylyl-imidodiphosphate, sodium fluoride, glucagon prostaglandin E2, addition the adenylate tumour isoprenaline. Glucose I2 (prostacyclin) did not stimulate either tumour, although stimulated insulin secretion cultures tumour. The vitro responsiveness correlate closely with effect on vivo.

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