Interaction of Histoplasma capsulatum with human macrophages, dendritic cells, and neutrophils.

摘要: Histoplasma capsulatum (Hc) is a dimorphic fungal pathogen indigenous to the Ohio and Mississippi River Valleys in United States. Infection initiated by inhalation of microconidia or small mycelial fragments into terminal bronchioles lung. The conidia are taken up alveolar macrophages (Mphi), which they convert pathogenic yeast phase. yeasts replicate Mphi other recruited lung as part inflammatory response. Thus, able disseminate from organs, such liver spleen. As facultative intracellular parasite, interaction Hc with critical component host response infection. In addition, have interactions neutrophils, dendritic cells (DCs) organs. Indeed, recent new evidence suggests that DCs may be key antigen-presenting initiate cell-mediated immunity. methods described this chapter cover quantitation binding, ingestion, replication human Mphi, DCs, neutrophils.