Myelodysplastic syndromes in Thailand: a retrospective pathologic and clinical analysis of 117 cases

摘要: To gain more insight into the understanding of myelodysplastic syndromes (MDS) as they occur in Thailand, a retrospective clinicopathologic analysis was conducted patients (age > 15 years) diagnosed MDS from January 1992 to December 1996 at five major medical centers various geographic regions country. The central reviewers independently examined bone marrow and peripheral blood smears all classify disease according French-British-American (FAB) classification. There were total 117 eligible patients. median age 56 years (range 16-86). male:female ratio 1:1. Thirty-two percent younger than 40 years. frequency FAB subtypes RA/RARS, 54.7; RAEB, 23.1; CMML, 9.4; RAEB-T, 12.8%. Anemia most common symptom presenting 84.6% In 34 whom cytogenetics analysed, 44.1% revealed abnormalities. Of these, monosomy 7 trisomy 8 aberration, each being detected 26.7% Transfusions main therapeutic modality 80% Kaplan-Meier 5 year survival rate 29% for whole group with 24 months. Twenty-five had progressed acute myelogenous leukemia (AML) time disease-progression 23 CMML RAEB-T 58.4, 19.9, 10.7 8.7 months, respectively (P < 0.001). stepwise Cox regression percentage blasts only parameter significantly associated progression. On comparison data other countries, Thai is considerably lower western population but comparable asian countries. distribution are similar. prognostic features, however, lie rather degree observed cytopenia.