Association of TGFB1 29C/T and IL6 -572G/C polymorphisms with developmental hip dysplasia: a case–control study in adults with severe osteoarthritis

摘要: Developmental dysplasia of the hip (DDH) increases risk severe adult osteoarthritis (OA). Transforming growth factor-β1 (TGF-beta1) and interleukin-6 (IL-6) are included in pathogenesis OA, as well development musculoskeletal system. We investigated association single nucleotide polymorphisms (SNPs) known to reflect on circulating levels two cytokines, specifically, 29 T → C transition TGFB1 signal sequence (rs1800470) -572G → C transversion IL6 promoter (rs1800796), with DDH. conducted a case–control study consecutive unrelated adults OA scheduled for total arthroplasty. Cases, patients secondary DDH (n = 68) controls, (n = 152) were genotyped at loci. With adjustment age, sex genotype concurrent locus, cases more likely (OR = 2.42, 95%CI 1.08–5.43; p = 0.032) be homozygous locus 29, also (OR = 6.36, 2.57–15.7; p < 0.001) −572 than controls. Cases (OR = 11.3, 4.25–29.8; controls carry one three genotypes combining transition/transversion homozygosity both loci, or heterozygosity locus. Data suggest between (rs1800796) DDH, possibility TGF-beta1 IL-6 interaction pathogenesis.