TGF-β1 29T/C polymorphism and breast cancer risk: a meta-analysis involving 25,996 subjects

摘要: Transforming growth factor β1 (TGF-β1) is a cytokine, playing an important role in controlling cell proliferation and differentiation involved breast cancer. It was reported the 29T/C polymorphism TGF-β1 has been implicated cancer risk. However, studies on association between this remain conflicting. To derive more precise estimation of relationship, meta-analysis 10,341 cases 15,655 controls from fifty published case-control performed. Our analysis suggested that no with trend risk when using both dominant [odds ratio (OR) = 1.01, 95% confidence intervals (CI) 0.96-1.07] recessive models (OR 0.98, CI 0.89-1.08) to analyze data. In ethnic subgroups analysis, also did not appear be factors for larger scale primary are required further evaluate interaction specific populations.