Genetic polymorphisms of TGF-β1 & TNF-β and breast cancer risk
作者： Kyoung-Mu Lee , Sue Kyung Park , Nobuyuki Hamajima , Kazuo Tajima , Keun-Young Yoo
DOI: 10.1007/S10549-004-3859-2
关键词: Cancer 、 Oncology 、 Case-control study 、 Risk factor 、 Biology 、 Immunology 、 Odds ratio 、 Body mass index 、 Breast cancer 、 Genotype 、 Family history 、 Internal medicine
摘要: Objective. The proliferation of malignant breast epithelial cells is regulated by various stimuli including cytokines and growth factors, thus the variants those genes may modify cancer risk. To evaluate potential influences TGF-β1 T 29C TNF-β A252G gene polymorphisms on risk, a case–control study was conducted in Korea. Methods. Histologically confirmed cases (n = 560) controls (n=509) with no previous history were recruited from three teaching hospitals Seoul, Genotypes determined PCR-CTPP (polymerase chain reaction confronting two-pair primers) method. Odds ratios (ORs) 95% confidence intervals (CIs) calculated unconditional logistic regression model adjusting for age, body mass index, education, parity, age at first full-term pregnancy, family cancer. Results. 29C-allele containing genotypes posed an increased risk (OR=1.3, CI=1.02–1.79), especially postmenopausal women (OR=1.6, CI=1.01–2.44). Similarly, TNF-β 252G-allele (OR=1.7, CI=1.09–2.55). parallel number (p trend 22.8 kg/m2) (OR=1.9, CI=1.04–3.37). Conclusion. results this therefore suggest that individual susceptibility to Korean women.
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