Statins and the Role of Nitric Oxide in Chronic Heart Failure

摘要: Endothelial dysfunction plays an important role in a number of cardiovascular diseases. An pathogenetic factor for the development endothelial is lack nitric oxide (NO), which potent endothelium-derived vasodilating substance. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins), originally designed to lower plasma cholesterol levels, seem ameliorate by mechanism so far only partly understood. However, statins increase synthase activity. It has been speculated that this and other “side effects” statin treatment are due inhibition Rho, intracellular signalling protein initiates Rho kinase transcription. Moreover, possess anti-inflammatory characteristics. Some have proven levels C-reactive protein, induced pro-inflammatory cytokines. Other demonstrated directly inhibit cytokine induction. Finally, some data suggest might be able counterbalance increased production oxygen free radicals. Since chronic heart failure accompanied not dysfunction, but also activation enhanced formation radicals, it tempting speculate ideal candidate treat certain features disease. The doses needed achieve desired effects much than those hypercholesterolemia.