Modulation of nuclear protein import: a novel means of regulating gene expression.

摘要: Eukaryotic cells depend upon the regulated exchange of proteins and RNA between cytoplasm nucleus for survival. Various cytoplasmic nuclear play a fundamental role in this specific transport process. Over last few years components stages protein have been characterized significant detail. Because many that are transported into transcription factors, import process is an interesting target manipulation gene expression. time eukaryotic cell has assembled number methods by which to regulate localization factors. Within years, there several reports pharmacologic as well. In addition, recent study suggests viruses able modulate host vivo. This report will present overview import, describe various vivo mechanisms regulates process, discuss attempts manipulate with small molecule compounds. As cellular potential opportunities future may arise from direct ways thereby treat diseases dysregulation factor activity.