Virus-resistant transgenic animals
作者： Thomas E. Wagner , Xiao-Zhuo Chen
DOI:
关键词:
摘要: A transgenic animal with enhanced viral resistance transmissible to its offspring is prepared by introduction of a gene encoding heterologous interferon having antiviral activity into host animal. The encodes the different species and therefore expression product less toxic at an embryonic, fetal, neonatal or juvenile stage development. Preferably, human beta introduced cells non-human
lens.org 参考文章(3)
Kaname Sugimoto, Shokichi Yuen, Interferon and preparations containing interferon ,(1979)
E. F. Wagner, T. A. Stewart, B. Mintz, The human beta-globin gene and a functional viral thymidine kinase gene in developing mice. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 78, pp. 5016- 5020 ,(1981) , 10.1073/PNAS.78.8.5016
ION GRESSER, MICHAEL G. TOVEY, CHANTAL MAURY, IVAN CHOUROULINKOV, Lethality of interferon preparations for newborn mice. Nature. ,vol. 258, pp. 76- 78 ,(1975) , 10.1038/258076A0