Replication defective viral vectors for infecting human cells

作者: James G. Respess , Douglas J. Jolly , Harry E. Gruber , Paul K. Laikind

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摘要: Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous auto-immune diseases are disclosed. More specifically, the recombinant present invention useful for (a) stimulating specific immune response to an antigen pathogenic antigen; (b) inhibiting function agent, such as virus; and (c) interaction agent with host cell receptor. In addition, eucaryotic cells infected with, pharmaceutical compositions containing retrovirus Various methods producing having unique characteristics, transgenic packaging animals insects also

参考文章(216)
F Mavilio, G Ferrari, S Rossini, N Nobili, C Bonini, G Casorati, C Traversari, C Bordignon, Peripheral Blood Lymphocytes as Target Cells of Retroviral Vector-Mediated Gene Transfer Blood. ,vol. 83, pp. 1988- 1997 ,(1994) , 10.1182/BLOOD.V83.7.1988.1988
RICHARD C. MULLIGAN, Construction of Highly Transmissible Mammalian Cloning Vehicles Derived from Murine Retroviruses Experimental Manipulation of Gene Expression. pp. 155- 173 ,(1983) , 10.1016/B978-0-12-372380-2.50012-3
Alexandra Joyner, Yusei Yamamoto, Alan Bernstein, CONSTRUCTION AND TRANSFER OF RECOMBINANT RETROVIRUS CLONES CARRYING THE HSV-1 THYMIDINE KINASE GENE Developmental Biology Using Purified Genes. pp. 535- 546 ,(1981) , 10.1016/B978-0-12-137420-4.50047-4
Thomas E. Wagner, Xiao-Zhuo Chen, Virus-resistant transgenic animals ,(1988)
Daniel W. Celander, Jack R. Lenz, William A. Haseltine, Craig A. Rosen, Ltr vectors, methods of preparation and use ,(1985)
C. Stratowa, J. Doehmer, Y. Wang, P.H. Hofschneider, Recombinant retroviral DNA yielding high expression of hepatitis B surface antigen. The EMBO Journal. ,vol. 1, pp. 1573- 1578 ,(1982) , 10.1002/J.1460-2075.1982.TB01357.X
C Rinaldo, X L Huang, Z F Fan, M Ding, L Beltz, A Logar, D Panicali, G Mazzara, J Liebmann, M Cottrill, High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors. Journal of Virology. ,vol. 69, pp. 5838- 5842 ,(1995) , 10.1128/JVI.69.9.5838-5842.1995
J Ferbas, E S Daar, K Grovit-Ferbas, W J Lech, R Detels, J V Giorgi, A H Kaplan, Rapid evolution of human immunodeficiency virus strains with increased replicative capacity during the seronegative window of primary infection. Journal of Virology. ,vol. 70, pp. 7285- 7289 ,(1996) , 10.1128/JVI.70.10.7285-7289.1996