作者: Ian Baxter Campbell , Alan Naylor , Paul John Beswick
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摘要: The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof in which: R0 represents halogen; R?1 R2? are independently selected from H, halogen, C?1-4?alkyl, C1-4alkyl substituted by one or more fluorine atoms, C1-4alkoxy, C1-4hydroxyalkyl, SC1-4alkyl, C(O)H C(O)C1-4alkyl; R?3? C?1-4?alkyl. Compounds potent selective inhibitors COX-2 use treatment pain, fever, inflammation a variety conditions diseases.