Monoclonal antibody that distinguishes between phosphorylated and nonphosphorylated histone H1

作者: D. Stave Kohtz , David E. Burstein

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摘要: The present invention relates to a monoclonal antibody (mAb) that binds selectively phosphorylated histone H1 and not nonphosphorylated its use. In one embodiment, the mAb of at 12D11 epitope as defined herein. second aspect, cell producing which has been shown distinguish between this epitope. another method for evaluating cells or tissue obtained from an individual presence dedifferentiated (or nondifferentiated) cells. Kits are also subject suitable practicing discussed above.

参考文章(2)
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K Ajiro, K Shibata, Y Nishikawa, Subtype-specific cyclic AMP-dependent histone H1 phosphorylation at the differentiation of mouse neuroblastoma cells. Journal of Biological Chemistry. ,vol. 265, pp. 6494- 6500 ,(1990) , 10.1016/S0021-9258(19)39354-8