EFFECTS OF (-)TETRAHYDROPALMATINE ON THE ISOLATED ILEUM OF GUINEA-PIG.

摘要: Summary Introduction: (-)tetrahydropalmatine (THP) is an isoquinoline alkaloid extracted from the Stephania glabra (Roxb) Miers and other species of plants. It produces sedation nervous system, which attributable to its action on dopaminergic receptors localized in brain cortex stem. Objective: To characterize effects THP as antagonist different types pharmacological receptors. Methods: The antago- nisms produced by THP, chlorpromazine papaverine vis a contractions induced acetylcholine, serotonin, histamine bradykinin isolated guinea- pig ileum were compared. Results: inhibited four agonists non-specific similar way papaverine, though former was three times less active that latter. However, much more markedly serotonin effects. Conclusion: These results interpreted basis structural similarity papaverine. presumable collateral will differ those since spec- trum unlike. This provide incentive for pharma- cological evaluation with view usage human beings account potential value agent acting central system low toxicity.