Immune reconstitution syndrome associated with opportunistic mycoses

摘要: Host immunity is essential in facilitating the eradication of infection. However, immunological recovery and an imbalance characterised by either suboptimum or excessive expression immune responses can also be harmful to host. Inflammatory triggered rapid resolution immunosuppression lead a series localised systemic reactions, termed reconstitution syndrome (IRS), that are often misconstrued as failure specific antifungal therapy eliminate offending fungal pathogen. Recognition IRS has become increasingly relevant context our current use potent immunosuppressive agents immunostimulators allow manipulation system. Whereas conceptual principles underscore adverse effects overzealous dysregulated response, they support role immunotherapies augment if induction endogenous inadequate for control