Indoleamine 2,3-dioxygenase (IDO) induced by Leishmania infection of human dendritic cells

摘要: Summary Dendritic cells (DC) play a pivotal role in regulating immunity, establishing immunologically privileged tissue microenvironments and maintaining homoeostasis. It is becoming increasingly clear that one key mechanism mediates many DC functions production of the immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO). For pathogens cause chronic infection, exploitation host DCs solution to establish persist within host. Leishmania parasites range clinical manifestations, all involving are proficient at avoiding immune responses. We demonstrate here infection human myeloid-derived with L. major L. donovani induces IDO expression using involves autocrine or paracrine stimulation DC-secreted factor. Leishmania-induced suppresses allogeneic tetanus toxoid–specific lymphocyte proliferation, an inhibition reversed inhibitor, 1-methyl tryptophan (1-MT). Furthermore, by does not require live as parasite lysates also up-regulate mRNA production. Our data suggest utilize circumvent clearance may be promote induction among microenvironment.