Exome sequencing on malignant meningiomas identified mutations in neurofibromatosis type 2 (NF2) and meningioma 1 (MN1) genes.
作者： Chengliang Dong , Jinghui Hou , Zheng Wang , Xu Zhang , Haiying Jia
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摘要: Background Meningiomas are tumors originating from the membranous layers surrounding central nervous system, and generally regarded as “benign” of brain. Malignant meningiomas rare typically associated with a higher risk local tumor recurrence poorer prognosis (median survival time <2 years). Previous genome-wide association studies exome sequencing have identified genes that play role in susceptibility to meningiomas, but these did not focus specifically on malignant tumors.
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