Accelerated Clearance of Ultrasound Contrast Agents Containing Polyethylene Glycol is Associated with the Generation of Anti-Polyethylene Glycol Antibodies.
作者： Samantha M. Fix , A. Gloria Nyankima , Morgan D. McSweeney , James K. Tsuruta , Samuel K. Lai
DOI: 10.1016/J.ULTRASMEDBIO.2018.02.006
关键词:
摘要: Abstract Emerging evidence suggests that the immune system can recognize polyethylene glycol (PEG), leading to accelerated blood clearance (ABC) of PEGylated particles. Our aim here was study generation anti-PEG immunity and changes in microbubble pharmacokinetics during repeated contrast-enhanced ultrasound imaging rats. We administered homemade microbubbles multiple times over a 28-d period observed dramatically (4.2 × reduction half-life), which associated with robust IgM IgG antibody production. Dosing animals free PEG as competition agent before administration significantly prolonged circulation, suggesting ABC largely driven by circulating antibodies. Experiments U.S. Food Drug Administration-approved Definity similarly resulted non-PEGylated Optison revealed slight shift clearance, indicating immunologic factors beyond may play role ABC, especially agents.
sci-hub.se 参考文章(64)
Moritz Palmowski, Jochen Huppert, Gesa Ladewig, Peter Hauff, Michael Reinhardt, Margareta M. Mueller, Eva C. Woenne, Juergen W. Jenne, Mathias Maurer, Guenter W. Kauffmann, Wolfhard Semmler, Fabian Kiessling, Molecular profiling of angiogenesis with targeted ultrasound imaging: early assessment of antiangiogenic therapy effects. Molecular Cancer Therapeutics. ,vol. 7, pp. 101- 109 ,(2008) , 10.1158/1535-7163.MCT-07-0409
Munehira Kawanishi, Yosuke Hashimoto, Taro Shimizu, Ikuko Sagawa, Tatsuhiro Ishida, Hiroshi Kiwada, Comprehensive analysis of PEGylated liposome-associated proteins relating to the accelerated blood clearance phenomenon by combination with shotgun analysis and conventional methods Biotechnology and Applied Biochemistry. ,vol. 62, pp. 547- 555 ,(2015) , 10.1002/BAB.1291
Igor Spivak, Anne Rix, Georg Schmitz, Stanley Fokong, Olga Iranzo, Wiltrud Lederle, Fabian Kiessling, Low-Dose Molecular Ultrasound Imaging with E-Selectin-Targeted PBCA Microbubbles. Molecular Imaging and Biology. ,vol. 18, pp. 180- 190 ,(2016) , 10.1007/S11307-015-0894-9
Sarah E. Shelton, Brooks D. Lindsey, James K. Tsuruta, F. Stuart Foster, Paul A. Dayton, Molecular Acoustic Angiography: A New Technique for High-resolution Superharmonic Ultrasound Molecular Imaging Ultrasound in Medicine and Biology. ,vol. 42, pp. 769- 781 ,(2016) , 10.1016/J.ULTRASMEDBIO.2015.10.015
Neville J. Butcher, Gysell M. Mortimer, Rodney F. Minchin, Drug delivery: Unravelling the stealth effect Nature Nanotechnology. ,vol. 11, pp. 310- 311 ,(2016) , 10.1038/NNANO.2016.6
Andrew W Appis, Melissa J Tracy, Steven B Feinstein, Update on the safety and efficacy of commercial ultrasound contrast agents in cardiac applications. Echo research and practice. ,vol. 2, ,(2015) , 10.1530/ERP-15-0018
Luca Caschera, Angelo Lazzara, Lorenzo Piergallini, Domenico Ricci, Bruno Tuscano, Angelo Vanzulli, Contrast agents in diagnostic imaging: Present and future. Pharmacological Research. ,vol. 110, pp. 65- 75 ,(2016) , 10.1016/J.PHRS.2016.04.023
Steven Machtaler, Ferdinand Knieling, Richard Luong, Lu Tian, Jürgen K. Willmann, Assessment of Inflammation in an Acute on Chronic Model of Inflammatory Bowel Disease with Ultrasound Molecular Imaging. Theranostics. ,vol. 5, pp. 1175- 1186 ,(2015) , 10.7150/THNO.13048
N G Lopez, P N Shek, T D Heath, Immune response mediated by liposome-associated protein antigens. IV. Modulation of antibody formation by vesicle-encapsulated methotrexate. Immunology. ,vol. 57, pp. 153- ,(1986)
P N Shek, T D Heath, Immune response mediated by liposome-associated protein antigens. III. Immunogenicity of bovine serum albumin covalently coupled to vesicle surface. Immunology. ,vol. 50, pp. 101- 106 ,(1983)