Infarct artery patency predicts outcome of serial electropharmacological studies in patients with malignant ventricular tachyarrhythmias.
作者： J T Hii , M Traboulsi , L B Mitchell , D G Wyse , H J Duff
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摘要: BACKGROUND Surviving myocardial cells near the infarct border zone form arrhythmogenic substrate for sustained ventricular tachycardia (VT) in humans. Infarct-related artery (IRA) patency may modulate electrophysiological function of this and its response to antiarrhythmic drug therapy. We postulated that effective therapy selected during serial studies patients with VT after a infarction would be identified more frequently when IRA is patent than chronically occluded. METHODS AND RESULTS Consecutive (n = 64) documented coronary disease remote presenting spontaneous or fibrillation (VF) were studied. These underwent 4 +/- 2 electropharmacological identifying 16 (25%) patients. Drug responders did not differ significantly from nonresponders demographic, electrocardiographic, angiographic, hemodynamic measurements. A was associated an occluded (45% versus 9%, p 0.001). Patency only independent predictor study population. The sensitivity specificity using predict successful testing 81% 67%, respectively. CONCLUSIONS outcome predicted by IRA. greater probability finding
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