Estimation of AUC or Partial AUC Under Test-Result-Dependent Sampling

摘要: The area under the receiver operating characteristic (ROC) curve (AUC) and partial ROC (pAUC) are summary measures used to assess accuracy of a biomarker in discriminating true disease status. standard sampling approach validation studies is often inefficient costly, especially when ascertaining status costly invasive. To improve efficiency reduce cost studies, we consider test-result-dependent (TDS) scheme, which subject selection for determining state dependent on result assay. We first estimate test-result distribution using data arising from TDS design. With estimated empirical distribution, propose consistent nonparametric estimators AUC pAUC establish asymptotic properties proposed estimators. Simulation show that have good finite sample d...