Numerical Investigation of the Effects of Channel Geometry on Platelet Activation and Blood Damage

摘要: Thromboembolic complications in Bileaflet mechanical heart valves (BMHVs) are believed to be due the combination of high shear stresses and large recirculation regions. Relating blood damage design geometry is therefore essential ultimately optimize BMHVs. The aim this research quantitatively study effect 3D channel on shear-induced platelet activation aggregation, choose an appropriate index (BDI) model for future numerical simulations. simulations use a recently developed lattice-Boltzmann with external boundary force (LBM-EBF) method [Wu, J., C. K. Aidun. Int. J. Numer. Method Fluids 62(7):765–783, 2010; Wu, Multiphase flow 36:202–209, 2010]. geometries conditions re-constructed from recent experiments by Fallon [The Development Novel vitro Flow System Evaluate Platelet Activation Procoagulant Potential Induced Mechanical Heart Valve Leakage Jets School Chemical Biomolecular Engineering. Atlanta: Georgia Institute Technology] et al. [Ann. Biomed. Eng. 36(1):1]. fluid computed fixed regular ‘lattice’ using LBM, each mapped onto Lagrangian frame moving continuously throughout domain. two-way fluid–solid interactions determined EBF enforcing no-slip condition surface. motion orientation obtained Newtonian dynamics equations. results show that sharp corners or sudden shape transitions will increase damage. Fallon’s experimental were used as basis choosing BDI computational through