Preoperative diagnosis of extrapancreatic neural invasion in pancreatic cancer.

摘要: Background & Aims: Pancreatic cancer recurs in most patients after resection with curative intent. Recurrence is particularly common extrapancreatic neural invasion (EPNI), the presence of which correlates poor prognosis. Macroscopic EPNI may be detected conventional noninvasive imaging and endoscopic ultrasound (EUS) imaging, but microscopic has required postoperative pathologic examination surgical specimens. We report preoperative diagnosis infiltration into celiac ganglia. hypothesized that pancreatic metastasis to ganglia can by EUS-guided biopsy examination. Methods: performed a retrospective review undergoing EUS whom were sampled exclude malignant infiltration. Results: Six underwent fine-needle aspiration or trucut presumed Metastatic was found 2 patients. Specimen identified adenocarcinoma tissue absence lymphocytes. At laparoscopy, 1 positive specimens also had several unexpected peritoneal metastatic deposits. The other patient considered have locally advanced unresectable disease. Both are receiving supportive care. Conclusions: shown preoperatively using sampling A potential improve staging accuracy outcomes.