4-Toluenesulfonyloxymethyl-(H)-phosphinate: A Reagent for the Introduction of O- and S-Methyl-(H)-phosphinate Moieties.

摘要: The straightforward synthesis of sodium 4-toluenesulfonyloxymethyl-(H)-phosphinate and (H)-phosphinomethylisothiouronium tosylate as new reagents for the preparation O- S-methyl-(H)-phosphinic acid derivatives, respectively, is described. reactivity both was demonstrated by protected 2′-deoxyribonucleoside-O-methyl-(H)-phosphinates in 5′- 3′-series 2′,5′-dideoxyribonucleoside-5′-S-methyl-(H)-phosphinates. These compounds represent a class monomers compatible with solid phase oligonucleotides H-phosphonate chemistry, it proved fully phosphonate heptamer.