Novel, potent, and orally bioavailable phosphinic acid inhibitors of the hepatitis C virus NS3 protease.
作者： Michael O. Clarke , Xiaowu Chen , Aesop Cho , William E. Delaney , Edward Doerffler
DOI: 10.1016/J.BMCL.2011.04.125
关键词:
摘要: A potent and novel class of product-like inhibitors the HCV NS3 protease was discovered by employing a phosphinic acid as carboxylate isostere. The replicon activity pharmacokinetic profile this series compounds optimized exploring substitution acid, well conformationally constraining these through macrocyclization. syntheses preliminary biological evaluation acids is described.
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