Multiple endocrine abnormalities of the growth hormone and insulin-like growth factor axis in prepubertal children with exogenous obesity : Effect of short- and long-term weight reduction

摘要: We have studied the GH-insulin-like growth factor (IGF) axis in prepubertal children with exogenous obesity at time of clinical diagnosis and two points during weight reduction on a calorie-restricted diet. Spontaneous GH secretion, IGF-I, free IGF-I (fIGF-I), IGF-II, their binding proteins (IGFBP-1, IGFBP-2, IGFBP-3), GH-binding protein (GHBP) values (n = 65), after 25% decrease body mass index (BMI) expressed as sd score (BMI score; n 29), diminution least 50% initial BMI 9) are reported. secretion was significantly reduced diagnosis, score, it returned to normal all patients. Total levels were not different from those controls any point. In contrast, fIGF-I IGF-II increased, both reduction. Obese patients hyperinsulinemic diagno...