Lithogenic risk factors for renal stones in patients with Crohn's disease.

摘要: OBJECTIVES Calcium oxalate kidney stones are more common in patients with Crohn's disease (CD). The aims of this study were to verify the prevalence main risk factors for calcium nephrolithiasis CD and evaluate degree urinary relative supersaturation (CaOx), dihydrogen uric acid (DHUA) monohydrogen phosphate (MHCaP). SUBJECTS AND STUDY PROTOCOL: 42 (22 male 20 female, aged 15-72 years) 18 controls (8 10 26-65) studied. Nine evaluated during an active episode 33 a quiescent phase. All had normal glomerular filtration rate. subjects collected 24-hr urine sample fasting venous blood was drawn. Good compliance collection assessed by Cockcroft Gault formula. In pH (Ox), (Ca), (P), (UA), citrate (Cit), magnesium (Mg), sulphate (Sulph), sodium, potassium chloride concentrations measured their excretions calculated. Urinary RS index obtained using software EQUIL93. RESULTS A decreased volume (61.9%) most frequent finding. excretion Cit, Mg Sulph (38.1%, 31.0% 31.0%, respectively) increased P, Ox, UA Ca (33.3%, 23.8%, 16.7% 14.3%, found. Thirty four (81.0%) showed at least 2 lithogenic only none. Urine higher CaOx DHUA super saturation. Patients studied MHCaP than those period. CONCLUSIONS majority have multifactorial high single patient usually has several metabolic disturbances which evident episode.