Oxalate crystal deposition disease.

摘要: In addition to monosodium urate, calcium pyrophosphate dihydrate, and apatite crystals, oxalate crystals are less often found in synovial fluids association with acute or chronic arthritis. Oxalate crystal deposition disease is seen patients primary hyperoxaluria types 1 2 (PH1 2) end-stage renal managed long-term dialysis. deposits mainly kidneys, bone, skin, vessels, inside the joints. Musculoskeletal systemic manifestations of may be confused those observed other most common diseases. Clinical radiographic features include osteopathy, arthropathy chondrocalcinosis, calcification, miliary skin vascular calcifications that affect hands feet. Systemic life-threatening cardiovascular, neurologic, hematologic rare. Genomic DNA studies have identified genetic defects PH1 PH2 allow a precise early diagnosis. Kidney transplantation has poor outcome as result graft oxalosis. Combined liver kidney treatment choice advanced failure. Pre-emptive isolated preferred who develop during infancy progressive These novel findings understanding molecular enzymatic aspects hyperoxalurias provided more rational basis for management prevention disease. This information lead better effective calcium-containing