Regorafenib for gastrointestinal malignancies : from preclinical data to clinical results of a novel multi-target inhibitor

作者: Giuseppe Aprile , Marianna Macerelli , Francesco Giuliani

DOI: 10.1007/S40259-013-0014-9

关键词:

摘要: … KIT, RET and V600 mutant BRAF. Starting from interesting preclinical results, this review describes the clinical development of regorafenib in gastrointestinal malignancies, focusing on …

参考文章(62)
誠 上野, 秀樹 上野, 2011 ASCO Annual Meeting 膵・胆道癌frontier. ,vol. 1, pp. 56- 61 ,(2011)
Peter Blume-Jensen, Tony Hunter, Oncogenic kinase signalling. Nature. ,vol. 411, pp. 355- 365 ,(2001) , 10.1038/35077225
Scott M. Wilhelm, Jacques Dumas, Lila Adnane, Mark Lynch, Christopher A. Carter, Gunnar Schütz, Karl-Heinz Thierauch, Dieter Zopf, Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity International Journal of Cancer. ,vol. 129, pp. 245- 255 ,(2011) , 10.1002/IJC.25864
Josep M Llovet, Sergio Ricci, Vincenzo Mazzaferro, Philip Hilgard, Edward Gane, Jean-Frédéric Blanc, Andre Cosme De Oliveira, Armando Santoro, Jean-Luc Raoul, Alejandro Forner, Myron Schwartz, Camillo Porta, Stefan Zeuzem, Luigi Bolondi, Tim F Greten, Peter R Galle, Jean-François Seitz, Ivan Borbath, Dieter Häussinger, Tom Giannaris, Minghua Shan, Marius Moscovici, Dimitris Voliotis, Jordi Bruix, None, Sorafenib in Advanced Hepatocellular Carcinoma The New England Journal of Medicine. ,vol. 359, pp. 378- 390 ,(2008) , 10.1056/NEJMOA0708857
Peter Carmeliet, VEGF as a key mediator of angiogenesis in cancer. Oncology. ,vol. 69, pp. 4- 10 ,(2005) , 10.1159/000088478
T Yokota, T Ura, N Shibata, D Takahari, K Shitara, M Nomura, C Kondo, A Mizota, S Utsunomiya, K Muro, Y Yatabe, BRAF mutation is a powerful prognostic factor in advanced and recurrent colorectal cancer British Journal of Cancer. ,vol. 104, pp. 856- 862 ,(2011) , 10.1038/BJC.2011.19
Rob Brierley, 2009 ASCO Annual Meeting Lancet Oncology. ,vol. 10, pp. 650- ,(2009) , 10.1016/S1470-2045(09)70181-0
Bernard Escudier, Tim Eisen, Walter M Stadler, Cezary Szczylik, Stéphane Oudard, Michael Siebels, Sylvie Negrier, Christine Chevreau, Ewa Solska, Apurva A Desai, Frédéric Rolland, Tomasz Demkow, Thomas E Hutson, Martin Gore, Scott Freeman, Brian Schwartz, Minghua Shan, Ronit Simantov, Ronald M Bukowski, None, Sorafenib in advanced clear-cell renal-cell carcinoma. The New England Journal of Medicine. ,vol. 356, pp. 125- 134 ,(2007) , 10.1056/NEJMOA060655
D Strumberg, M E Scheulen, B Schultheis, H Richly, A Frost, M Büchert, O Christensen, M Jeffers, R Heinig, O Boix, K Mross, Regorafenib (BAY 73-4506) in advanced colorectal cancer: a phase I study. British Journal of Cancer. ,vol. 106, pp. 1722- 1727 ,(2012) , 10.1038/BJC.2012.153
Miles A Fabian, William H Biggs, Daniel K Treiber, Corey E Atteridge, Mihai D Azimioara, Michael G Benedetti, Todd A Carter, Pietro Ciceri, Philip T Edeen, Mark Floyd, Julia M Ford, Margaret Galvin, Jay L Gerlach, Robert M Grotzfeld, Sanna Herrgard, Darren E Insko, Michael A Insko, Andiliy G Lai, Jean-Michel Lélias, Shamal A Mehta, Zdravko V Milanov, Anne Marie Velasco, Lisa M Wodicka, Hitesh K Patel, Patrick P Zarrinkar, David J Lockhart, A small molecule–kinase interaction map for clinical kinase inhibitors Nature Biotechnology. ,vol. 23, pp. 329- 336 ,(2005) , 10.1038/NBT1068