Calcium Channel Blocking Agents and Risk of Cancer in Patients With Coronary Heart Disease

摘要: Abstract Objectives. This analysis sought to estimate the risk ratio for cancer incidence and cancer-related mortality associated with use of calcium channel blocking agents (CCBs) in a large group patients chronic coronary heart disease (CHD). Background. Recent publications contend that short-acting CCBs may double possibly increase hypertensive patients. Methods. Cancer data were obtained 11,575 screened Bezafibrate Infarction Prevention (BIP) study, one-half whom treated at time screening CCBs, over mean follow-up period 2.8 years. Cause-specific was available through September 1996 (mean 5.2 years). The statistical power detecting an odds ≥1.5 (given rate 2.1 nonusers CCBs) 0.91. declined 0.77, 0.54 0.41, declining ratios 1.4, 1.3 1.25, respectively. Results. Of 246 incident cases, 129 occurred among users (2.3%) 117 (2.1%). After adjustment age, gender smoking, estimates all cancers combined 1.07 (95% confidence interval [CI] 0.83 1.37) CCB relative nonusers. adjusted all-cause smoking pertinent prognostic clinical characteristics estimated 0.94 CI 0.85 1.04). 1.03 0.75 1.41). Conclusions. Patients CHD exhibited similar total compared CCBs. provides certain assurance middle-aged elderly is not meaningful difference related mortality.