The research of W.E. Mayer (1953–2012): a spectrum of immune systems

摘要: Over a period of some 20 years, Werner Eugen Mayer played significant role in establishing framework for molecular studies Mhc genes multiple vertebrates. His work largely concerned gene isolation, sequencing, and related bioinformatic analyses both the immune system about 200 species, ranging from apes, monkeys, rodents, marsupials, through to birds, bony fishes, lampreys. In addition his exploration diverse genes, is remembered playing critical development two important insights into evolution systems. was among first published DNA sequence-based descriptions trans-species alleles, including description long-lived polymorphisms shared by humans chimpanzees. This research opened way using demographic analyses. The second insight which he prominent involved characterization cells their expressed lamprey, jawless vertebrate. findings helped indicate considerable degree extant mechanisms were co-opted creation adaptive jawed