Proteolytic enzymes in ordinary, hyperacute, monocytic and passive transfer forms of experimental allergic encephalomyelitis

摘要: Abstract The changed patterns of proteolytic activity in brain and spinal cord Lewis rats were examined 4 different morphological variants EAE: ordinary induced by the standard emulsion, hyperacute an emulsion plus pertussis vaccine, passive donor EAE cells, monocytic treatment with immunosuppressive drug tilorone. following enzymatic changes found: firstly, there was a 2–3.5-fold increase cathepsins A C (E.C. 3.4.14.1) one day appearance paralysis smaller change hindbrain, none forebrain regions. With recovery from paralysis, levels cathepsin remained high upper cord, fell to about half. In contrast, D (E.C.3.4.23.5) occurred only 4–5 days after largest areas small decrease on paralysis. Secondly, EAE, all cases level cord. most significant lower for C, fourthly, tilorone, exceptionally large, 3-fold as compared 1.5–2 fold other cathepsins. No major differences observed comparison antigens sources (guinea pig bovine myelin peptide). An attempt is made relate features each variant special reference nature infiltrating cells.