The Role of Hypoxia-Induced Factors

摘要: The definition of “physiologically” normoxic conditions for either embryonic or adult cells varies significantly. vast majority normal tissues function at oxygen (O2) levels between 2 and 9%, with ambient air 21% O2 [135]. Bone marrow, cartilage, kidney medulla, thymus, on the other hand, can exist 1% lower In general, when tension reaches below 2%, this condition is considered to be moderate hypoxia. When goes 0.5%, hypoxia severe. Hypoxia not only a pathophysiological component many human disorders, including cancer ischemic diseases, but also critical factor in fetal development differentiation [21, 39, 82]. Before circulatory system established, mammalian proceeds relatively low environment about 3% [100, 120]. Moreover, studies that have utilized small-molecule markers shown existence specific regions severe developing embryos