Evaluation of a Discontinuous Treatment Protocol (VELCAP‐S) for Canine Lymphoma

摘要: Eighty-two dogs with lymphoma received a single 15-week course of chemotherapy, after which treatment was ceased until relapse. Fifty-six (68%) achieved complete remission for median 1st duration 20 weeks. Forty-eight relapsed, 30 repeated the induction cycle. In 22 these dogs, had been short, and they maintenance chemotherapy; other 8 2 or 3 cycles chemotherapy. Second rate 87% (26 dogs). Overall disease control 38 that remained on protocol 44 weeks, not markedly shorter than treated previously reported in chemotherapy instituted all an identical (VELCAP-L). Dogs were febrile dyspneic less likely to achieve Of remission, those thrombocytopenic at entry anorexic overall control. There correlation between length any subsequent obtained. The incidence toxicity high, particularly combination doxorubicin vincristine. Dose reductions because did reduce duration. We conclude discontinuous may patient visits small number patients long-term Delaying 2nd is does affect