Analysis of the complete nucleotide sequence of African swine fever virus.

摘要: We present an analysis of the complete genome African swine fever virus (ASFV) strain BA71V, including 80 kbp novel sequence and 90 previously reported by several authors. The viral DNA is 170,101 nucleotides long contains 151 open reading frames. Structural and/or functional information available on 113 proteins. ASFV encodes five multigene families, putative membrane secreted proteins, enzymes involved in nucleotide nucleic acid metabolism (including repair) protein modification. Database comparisons have provided clues about genes that may modulate virus-host interaction, thus, possibly controlling virulence persistence. possesses similar to CD2, IkappaB, C-type lectins, MyD116/gadd34/gamma, 34.5, bcl-2/bax, iap, NifS, ERV1, which allow a regulation cell adhesion, apoptosis, redox metabolism, as well host immune response against infection. proteins encoded different isolates are highly similar, most variable ones being those belonging some containing tandem repeats. data confirm intermediate characteristics between poxviruses iridoviruses, supporting notion belongs independent family.