Signaling by the G12 class of G proteins.

摘要: Abstract The G12 class of G proteins are defined by the α-subunits mammalian and G13. Biochemical mutational characterization α 12 13 have identified several novel signaling pathways regulated these α-subunits. Studies with constitutively activated mutants Gα12 Gα13 indicated that they stimulate mitogenic leading to oncogenic transformation fibroblast cell lines. Recent analyses regulate cytoplasmic as well nuclear events such activation Jun N-terminal kinase module, Na+/H+ exchangers, focal adhesion assemblies, transcriptional specific primary response genes. emerging view suggests represent an integrated This review discusses diverse responses G13, interrelationship responses.