Extensive chromosome rearrangements distinguish the karyotype of the hypovirulent species Candida dubliniensis from the virulent Candida albicans.

摘要: Candida dubliniensis and albicans, the most common human fungal pathogen, have of same genes high sequence similarity, but C. is less virulent. albicans causes both mucosal hematogenously disseminated disease, mostly infections. Pulse-field electrophoresis, genomic restriction enzyme digests, Southern blotting, emerging from Wellcome Trust Sanger Institute were used to determine karyotype type strain CD36. Three chromosomes two intact homologues. A translocation in rDNA repeat on chromosome R exchanges telomere-proximal regions 5. Translocations involving remaining occur at Major Repeat Sequence. CD36 lacks an MRS has one 3. Of six other strains, no had electrophoretic karyotype. Despite extensive rearrangements, karyotypic differences between are unlikely affect gene expression. Karyotypic instability may account for diminished pathogenicity dubliniensis.