Limited utility of fluorescence in situ hybridization for common abnormalities of myelodysplastic syndrome at first presentation and follow-up of myeloid neoplasms.

摘要: Fluorescence in situ hybridization for abnormalities common to myelodysplastic syndrome (MDS FISH) is often used with traditional karyotype the diagnosis and monitoring of myeloid neoplasms. However, its value these roles has been questioned. To evaluate utility, we compared MDS FISH results 544 bone marrow specimens obtained (180 cases) or follow-up (364 neoplasia. We found excellent concordance between karyotype, such that rarely abnormal (1.7% at 3.0% follow-up) cases normal karyotype. Even rare discordant cases, little no clinical value. Thus, propose this test should be limited inadequate only. Such guidelines could result significant cost savings impact on patient diagnosis.