Cryptorchidism in Boys With Cerebral Palsy Is Associated With the Severity of Disease and With Co-Occurrence of Other Congenital Anomalies.

摘要: Background: Cryptorchidism is reported in 40-50% of small case series cerebral palsy (CP), and attributed to hypothalamic-pituitary-gonadal axis abnormalities, intellectual disability or cremaster spasticity. We collected demographic clinical data define the frequency cryptorchidism comorbidities a large CP population. Methods: Electronic health record (EHR) were for all male patients ≥7 years age seen large, multidisciplinary clinic between 2000 2016. Variables including age, testicular position, surgical findings, severity, birth history, tested association using univariable stepwise backward logistic regression analyses. Results: Of 839 established patients, testis position was scrotal 553, undescended 185 (24%), retractile 38 (5%) undocumented 63 cases. diagnosed at mean 5.8 years, with 20% documented as acquired, testes most commonly superficial inguinal pouch (41%) associated an hernia (56%). Severity bilateral 114/166 (69%) 24/36 (66%) cases, respectively. Mean weight prematurity (55, 58 54%) multiple (14, 13, 9%) not significantly different among three groups. observed strong ordinal trend comorbidities, quadriplegia, syndromic features/known genetic disease, intrauterine growth restriction (IUGR), death, brain malformations, seizures, gastrostomy, absent continence, hearing, speech visual impairment, group holding intermediate majority. The multivariable analysis showed independent positive associations hearing loss, inverse gestational birth. Conclusion: These suggest that less common than previously but strongly quadriplegia. Delayed diagnosis may be related acquired condition additional functional deficits occur this Our UDT both components malformation syndromes occurring singleton births whose features are more likely include earlier delivery, IUGR, loss and/or global